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Found 3 of ec50 for NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
having polymerids = 50007610 and
complexids = 50016027
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataEC50:  30nMAssay Description:Inhibition of NAE in human HCT-116 cells incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM67690(1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8-bis...)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of NAE-mediated Ubcl2-NEDD8 conjugation in human Caco2 cells after 16 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 catalytic/regulatory subunit(Homo sapiens)
University Of Macau

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of NAE-mediated Ubcl2-NEDD8 conjugation in human Caco2 cells after 16 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed